Endocrine Abstracts

This multi centre observational cohort study gives a view about the occurrence, clinical and laboratory presentation, localization, histological type and genetic background of pheochromocytoma (PHEO) and paraganglioma (PGL) in Eastern Slovakia. It included 28 patients (18 women +10 men), of which 23 were diagnosed to have PHEO (82.1%) and seven patients (25%) suffered from PGL with retroperitoneal, inguinal/pelvic and mediastinal distribution. Arterial hypertension was the maj...

It is well known that adrenal masses, particularly adenomas are frequently related to metabolic syndrome and insulin resistance. However, there are no reported data about the differences between adenomas and hyperplasia.Authors examined the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+15 years. 15 patients had adrenal adenoma determined by CT or ...

Objectives: Aim of the study was firstly to assess the prevalence of metabolic symptoms in patients with clinically silent and benign adrenal incidentalomas (AI) and secondly to determine the prevalence of C825T GNB3 gene polymorphism in AI as well as its relation to metabolic variables.Subject and methods: Group of patients consisted of 50 patients with AI of mean age 57.9±15 years and group of controls consisted of 22 subjects without AI and metab...

Acromegaly is usually diagnosed after several years of duration. The multimodal therapy – surgery, radiotherpy, pharmacotherapy – is necessary in the majority of patients. Register of sellar tumors (RESET) collecting data of patients from eight tertiary centers in the Czech and Slovak Republics since the year 2000 was established in 2008.Aim of analysis: Evaluation of diagnostics of acromegaly and effectiveness of its treatment in a daily pract...